The Appendix: Useful and in Fact Promising

Charles Q. Choi

The body's appendix has long been thought of as nothing more than a worthless evolutionary artifact, good for nothing save a potentially lethal case of inflammation.

Now researchers suggest the appendix is a lot more than a useless remnant. Not only was it recently proposed to actually possess a critical function, but scientists now find it appears in nature a lot more often than before thought. And it's possible some of this organ's ancient uses could be recruited by physicians to help the human body fight disease more effectively.

In a way, the idea that the appendix is an organ whose time has passed has itself become a concept whose time is over.

"Maybe it's time to correct the textbooks," said researcher William Parker, an immunologist at Duke University Medical Center in Durham, N.C. "Many biology texts today still refer to the appendix as a 'vestigial organ.'"

Slimy sac

The vermiform appendix is a slimy dead-end sac that hangs between the small and large intestines. No less than Charles Darwin first suggested that the appendix was a vestigial organ from an ancestor that ate leaves, theorizing that it was the evolutionary remains of a larger structure, called a cecum, which once was used by now-extinct predecessors for digesting food.

"Everybody likely knows at least one person who had to get their appendix taken out - slightly more than 1 in 20 people do - and they see there are no ill effects, and this suggests that you don't need it," Parker said.

However, Parker and his colleagues recently suggested that the appendix still served as a vital safehouse where good bacteria could lie in wait until they were needed to repopulate the gut after a nasty case of diarrhea. Past studies had also found the appendix can help make, direct and train white blood cells.

Now, in the first investigation of the appendix over the ages, Parker explained they discovered that it has been around much longer than anyone had suspected, hinting that it plays a critical function.

"The appendix has been around for at least 80 million years, much longer than we would estimate if Darwin's ideas about the appendix were correct," Parker said. READ MORE